发明名称 |
SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY |
摘要 |
This invention relates to substituted bicyclic dihydropyrimidinones of formula (1) and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases. |
申请公布号 |
WO2016016368(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
WO2015EP67506 |
申请日期 |
2015.07.30 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
OOST, THORSTEN;ANDERSKEWITZ, RALF;GNAMM, CHRISTIAN;MORSCHHAEUSER, GERD;PETERS, STEFAN;RIES, UWE JOERG |
分类号 |
C07D239/70;A61K31/517;A61P29/00 |
主分类号 |
C07D239/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|