MATERIALS FOR GASTROINTESTINAL OBSTRUCTION PREVENTION

摘要

Materials and methods for preventing gastrointestinal obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.

主权项

1. A method of preventing gastrointestinal obstruction in a subject comprising:
introducing a catheter into a gastrointestinal tract; positioning an end of the catheter in a target area of the gastrointestinal tract in which at a prevention of gastrointestinal obstruction is desired; administering through the catheter a solution comprising a self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to form a hydrogel under conditions of the gastrointestinal tract to provide prevention of gastrointestinal obstruction; and removing the catheter from the gastrointestinal tract.