| 摘要 |
The invention discloses a pharmaceutical composition comprising as active ingredient 5 to 20 wt.% ezetimibe, 50 to 85 wt.% diluent, 3 to 25 wt.% disintegrant, 2 to 5 wt.% solubility enhancer, 1 to 10 wt.% binder, and 0.5 to 1 wt.% lubricant, characterized in that the ezetimibe has a particle size distribution of d(0.9) of 9 to 20 μm and d(0.5) of 3 to 50 μm. The application further relates to a method for the preparation of a pharmaceutical composition in accordance with the present invention and to the use of ezetimibe having said particle size distribution for producing a medicament. The application also relates to the use of a corn starch paste containing at least 11 wt.% of a corn starch for preparing a pharmaceutical composition in accordance with the present invention. |
