| 主权项 |
1. A compound of the Formula (I)or a pharmaceutically acceptable salt thereof, whereinB is pyridyl;
wherein B is unsubstituted or substituted by 1 to 3 R3 moieties, wherein each R3 moiety is independently selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluoroalkyl, C1-C3 hydroxyalkyl, halo, hydroxy, amino, (C1-C3 alkyl)amino, di(C1-C3 alkyl)amino, —N(H)SO2—(C1-C3 alkyl), —CO2H, —C(O)NH2, —C(O)N(H)(C1-C3 alkyl), —C(O)N(H)(C1-C3 alkyl)2, —CH2O—(C1-C4 alkylene)-OH, and E; E is
(a) -E′,(b) —CH2-E1 or(c) —O—CH2-E1;wherein E1 is:
(i) phenyl; or(ii) C3-C6 cycloalkyl;wherein E1 is unsubstituted or substituted by 1 to 2 moieties independently selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, halo, hydroxy, nitro, carboxy, C1-C3 hydroxyalkyl, —O—(C1-C3 fluoroalkyl), —C(H)(OH)—(C1-C3 fluoroalkyl), —N(CH3)SO2—(C1-C3 alkyl), and RE1;
wherein RE1 is(a) —(CH2)x—RE1a, wherein x is 1, 2, or 3; or(b) —RE1a;wherein RE1a is phenyl; wherein RE1a is unsubstituted or substituted by 1 to 2 moieties independently selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy and halo;A is selected from the group consisting of
(a) wherein
Y is —CH—;R11 and R12 are independently H or F; andn is 1 or 2;n′ is 0 or 1; or (b) wherein
Ra and Rb are independently H, C1-C6 alkyl, or phenyl;
or Ra and Rb together with the carbon atom to which they are attached form —C(O)—;Q is —C(O)—, or —CH2CH2—;
wherein Rc is H, C1-C6 alkyl, C1-C3 fluoroalkyl, C3-C6 cycloalkyl, —(CH2)rOR13, —C(O)NH2, —C(O)N(H)(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —(CH2)rS(O)tR14, —(CH2)r-phenyl, or —(CH2)rN(H)C(O)—(C1-C3 alkyl);
R13 is H or C1-C3 alkyl; andR14 is C1-C3 alkyl;r is 1 or 2;t is 0, 1, or 2;Rd is H or C1-C6 alkyl, orRc and Rd together with the carbon atom to which they are attached form a group of the formula wherein q is 1, 2, 3, or 4; or (c) wherein m is 1 or 2 and m′ is 0 or 1; (e) H; (f) —C(O)N(H)—(C1-C3 alkyl); and (g) —S(O)2CH2CH2NH2. |
