SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA
摘要
The invention provides LNA gapmer oligomers of between 10 -20 nucleobases in length,which have a total of 1 -3 phosphodiester internucleoside linkages. Such oligomers have been found to have superior bioavailability and have also been found to selectively accumulate in kidney cells.
申请公布号
WO2008113832(A2)
申请公布日期
2008.09.25
申请号
WO2008EP53314
申请日期
2008.03.19
申请人
SANTARIS PHARMA A/S;HANSEN, BO;OERUM, HENRIK;HANSEN, HENRIK FRYDENLUND;STRAARUP, ELLEN MARIE;NIELSEN, NIELS FISKER;HEDTJAERN, MAJ
发明人
HANSEN, BO;OERUM, HENRIK;HANSEN, HENRIK FRYDENLUND;STRAARUP, ELLEN MARIE;NIELSEN, NIELS FISKER;HEDTJAERN, MAJ
