IMPROVEMENTS IN THE PREPARATION OF INTERMEDIATES LEADING TO [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(4-BROMO-3-M ETHYL-5-PROPOXY-THIOPHEN-2YL)-METHANONE HYDROCHLORIDE.

摘要

The present invention is directed (i) to a method for the preparation of a compound of formula (8) by condensing the compound of formula (7) with acetone and (ii) to a method for the preparation of a compound of formula (13) by alkylating the compound of formula (8) using methyl bromoacetate. The compounds of formula (7,8) and (13) useful intermediates for the preparation of the compound of formula (I).