| 发明名称 | Formulation for stabilizing proteins, which is free of mammalian excipient | ||
| 摘要 | The present invention pertains to a formulation comprising a hydrophilic polymer, a mixture of a polyalcohol and a sugar, wherein the weight ratio of polyalcohol to sugar is between 2:1 to 5:1 (wt-%), a detergent, and wherein the formulation is free of stabilizing proteins. | ||
| 申请公布号 | US9198856(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201013138884 | 申请日期 | 2010.04.16 |
| 申请人 | MERZ PHARMA GmbH & CO. KGaA | 发明人 | Burger Markus;Mander Gerd J.;Taylor Harold Victor |
| 分类号 | A61K39/08;A61K9/00;A61K8/34;A61K8/60;A61K8/64;A61K8/73;A61K8/86;A61K9/08;A61K9/19;A61K38/48;A61K47/14;A61K47/26;A61K47/32;A61K47/36;A61Q19/00 | 主分类号 | A61K39/08 |
| 代理机构 | Hueschen and Sage | 代理人 | Hueschen and Sage |
| 主权项 | 1. A formulation consisting essentially of: (a) hyaluronic acid, (b) a mixture of a polyalcohol and a sugar, and wherein the weight ratio of polyalcohol to sugar is from 2:1 to 5:1 (wt-%), (c) a surfactant, and (d) a Clostridium botulinum toxin,wherein the formulation is free of human serum albumin (HSA), gelatin, histidine, lysine, methionine immunoglobulins. | ||
| 地址 | Frankfurt am Main DE | ||