| 发明名称 |
USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER |
| 摘要 |
The present invention is related to a compound of formula (I) a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of cancer, wherein X is selected from the group consisting of N—R1, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and R3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.; |
| 申请公布号 |
US2015313882(A1) |
申请公布日期 |
2015.11.05 |
| 申请号 |
US201314651053 |
申请日期 |
2013.12.10 |
| 申请人 |
CENTOGENE AG |
发明人 |
BELLER MATTHIAS;LUKAS JAN;FRECH MORITZ;JUNGHANSS CHRISTIAN;ROLFS ARNDT;PEWS-DAVTYAN ANAHIT |
| 分类号 |
A61K31/437;A61K45/06;A61K31/404 |
主分类号 |
A61K31/437 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula (I):a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof;for use in a method for the treatment and/or prevention of cancer,whereinX is selected from the group consisting of N—R1, O and S;R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen;R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; andR3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl. |
| 地址 |
Rostock DE |
