Stable glucagon peptide formulations

摘要

There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.

主权项

1. A liquid pharmaceutical formulation comprising
a. 15-20% (w/w) of glucagon; b. 7.5-10% (w/w) of a stabilizing agent selected from either a cationic or neutral surfactant; c. 3.75-5% (w/w) of an amino acid; d. 3.75-5% (w/w) of an organic acid; and e. a pharmaceutically acceptable diluent; and wherein the formulation has a pH between 2 and 3.