RADIOISOTOPE TRITHIOL COMPLEXES

摘要

The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.

主权项

1. A radioisotope trithiol complex according to Formula I: wherein each R1 is independently C1 to C5 substituted or unsubstituted hydrocarbyl; mM is a radioisotope; and X is a chemical moiety.