发明名称 |
GLYCO-ENGINEERED ANTIBODIES |
摘要 |
<p>The present invention relates to an antibody preparation comprising modified antibodies of a mammal or derivatives or fragments thereof, specific for an antigen, characterized in that €¢ the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and €¢ the ADCC activity of the preparation is by at least 10% less inhibited in an at least 10% serum solution comprising unspecific antibodies of the mammal than an unmodified antibody preparation of the mammal specific for the same antigen.</p> |
申请公布号 |
EP2044121(A2) |
申请公布日期 |
2009.04.08 |
申请号 |
EP20070801422 |
申请日期 |
2007.07.11 |
申请人 |
GREENOVATION BIOTECH GMBH |
发明人 |
SCHUSTER, MANFRED;KIRCHEIS, RALF;NECHANSKY, ANDREAS;JOST, WOLFGANG;GORR, GILBERT |
分类号 |
C07K16/28;C07K16/00;G01N33/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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