| 发明名称 | Fatty acid acetylated salicylates and their uses | ||
| 摘要 | The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative. | ||
| 申请公布号 | US9139516(B2) | 申请公布日期 | 2015.09.22 |
| 申请号 | US201213427654 | 申请日期 | 2012.03.22 |
| 申请人 | Catabasis Pharmaceuticals, Inc. | 发明人 | Milne Jill C.;Jirousek Michael R.;Bemis Jean E.;Smith Jesse J. |
| 分类号 | C07C69/86;C07C233/55;C07C69/94;C07C233/18;C07C233/49;C07C235/60;C07C237/22;C07C271/28;C07C275/42;C07D295/182;C07D295/192;C07C235/52 | 主分类号 | C07C69/86 |
| 代理机构 | Goodwin Procter LLP | 代理人 | Goodwin Procter LLP |
| 主权项 | 1. A synergistically active molecular conjugate comprising a salicylate covalently linked to an omega-3 fatty acid through a linker comprising a first amide and a second amide, wherein the first amide comprises a carbonyl provided by the salicylate and the second amide comprises a carbonyl provided by the fatty acid and the conjugate is capable of hydrolysis to produce free salicylate and free fatty acid; and wherein the synergistic activity is derived from in vivo delivery of the salicylate and of the fatty acid to a target tissue or a target cell together. | ||
| 地址 | Cambridge MA US | ||