METHOD FOR PRODUCING A COMPOSITION FOR TREATING A TOOTH LESION

摘要

The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.

主权项

1. A method for producing a composition suitable for treating a tooth lesion, comprising
a) providing a solution comprising a peptide that starts to undergo self-assembly at a pH below 7.5, wherein said solution has a pH which is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly; b) adding a compound that increases the pH of the solution to 8.0 or higher, said compound being sufficiently volatile to be removed during lyophilization; c) lyophilizing the solution; and d) optionally, dissolving the lyophilizate in an aqueous solution to obtain a solution with a pH that is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly, said solution comprising the peptide predominantly in its monomeric state.