Oligomer-protein tyrosine kinase inhibitor conjugates

摘要

The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water-soluble, non-peptidic oligomer.

主权项

1. A method for inhibiting a protein tyrosine kinase, the method comprising administering to a mammal a protein tyrosine kinase-inhibiting amount of a compound having the following structureor a pharmaceutically acceptable salt thereof, wherein X is a spacer moiety and POLY is a water-soluble, non-peptidic oligomer having from about 1 to about 30 monomers.