发明名称 Hypotonic aqueous composition with reduced chloride content, with or without phospholipids
摘要 An aqueous composition for application in a method for surgical or therapeutic treatment of the human or animal body or in a diagnostic procedure which is practiced on the human or animal body, the composition comprising osmotically active particles and containing less than 70 μl−1 of amniotic cells, the osmolarity of the composition being in the range from 240.0 mosm/l to less than 308.0 mosm/l, and the chloride ion concentration in the composition being not more than 130.0 mmol/l. An aqueous composition for application with an amniotic infusion, the composition containing less than 70 μl−1 of amniotic cells and comprising at least one surfactant, is also disclosed.
申请公布号 US9072755(B2) 申请公布日期 2015.07.07
申请号 US201213978052 申请日期 2012.01.04
申请人 发明人 Tchirikov Michael
分类号 A61K31/685;A01N57/26;A61K31/661;A61K31/688;A61K33/14 主分类号 A61K31/685
代理机构 Marshall, Gerstein & Borun LLP 代理人 Marshall, Gerstein & Borun LLP
主权项 1. An aqueous composition for application in a method for the surgical or therapeutic treatment of the human or animal body or in a diagnostic method performed on the human or animal body, the aqueous composition consisting essentially of: (a) water, sodium ions, potassium ions, calcium ions, chloride ions, and hydrogencarbonate ions; and (b) optionally at least one selected from the group consisting of magnesium ions, urea, uric acid, phosphate ions, glucose, lactate salts, citrate salts, copper ions, selenium ions, zinc ions, phospholipids, lipids, surfactant proteins, proteins, amniotic cells, and non-fetal DNA; wherein: the composition contains fewer than 70 amniotic cells per μl,an osmolarity of the composition is in the range from 240.0 mosm/l to less than 308.0 mosm/l,a lactate salt concentration in the composition ranges from 0.0 mmol/l to 20.0 mmol/l, anda chloride ion concentration in the composition is not more than 130.0 mmol/l.
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