| 主权项 |
1. A process for preparing rivaroxaban or a pharmaceutically acceptable salt thereof, the process comprising one or more steps selected from the group consisting of
(a) mixing a compound of formula (A)or a salt thereof, with an acylating agent to prepare a compound of formula (B) (b) crystallizing the compound of formula (B); (c) mixing the compound of formula (B) with a compound of formula (C)to prepare a compound of formula (D)or a salt thereof; where RA is halo or a protected amino group; and RB is halo, amino or a salt thereof, or a protected amino group;
(d) crystallizing the compound of formula (D); (e) converting the compound of formula (D) or a salt thereof, where RB is halo, or a protected amino group, into a compound of formula (E)or a salt thereof;
(f) converting the compound of formula (D) or a salt thereof, where RB is halo, or a protected amino group, into a compound of formula (F) (g) reducing the compound of formula (F) or a salt thereof, into a compound of formula (E) (h) mixing the compound of formula (E) or a salt thereof with an acylating agent to prepare rivaroxaban, or a salt thereof; and (i) crystallizing rivaroxaban or a salt thereof from an organic acid; and combinations thereof. |
