IMMUNOGENIC COMPOUNDS COMPRISING HIV GP41 PEPTIDE COUPLED TO CRM197 CARRIER PROTEIN

摘要

The present invention relates to the field of vaccines directed against viruses of the HIV family. More particularly, it relates to an immunogenic compound comprising a peptide of the following formula (I) NH2-[Nt]y-P-W-N-X-S-X2-S-N-X3-X4-X-X6-X7-I-W-[Ct]z-COOH (I) which is covalently linked to a carrier protein consisting of a CRM197 protein. It also concerns a composition containing this immunogenic compound and the uses of these immunogenic compounds and compositions for preventing and/or treating a condition caused by the infection of an individual with a HIV virus.

主权项

1. An immunogenic compound comprising a peptide of the following formula (I)
NH2-[Nt]y-P-W-N-X1-S-X2-S-N-X3-X4-X5-X6-X7-I-W-[Ct]zCOOH  (I),wherein:
y is an integer meaning 0 or 1, z is an integer meaning 0 or 1, Nt consists of a peptide having from 1 to 100 amino acids in length, Ct consists of a peptide having from 1 to 100 amino acids in length, X1 is an amino acid selected from the group consisting of A (Alanine), T (threonine), S (Serine) and N (Asparagine), X2 is an amino acid selected from the group consisting of W (Tryptophane) and A (Alanine), X3 is an amino acid selected from the group consisting of K (Lysine) and R (Arginine, X4 is an amino acid selected from the group consisting of S (Serine) and T (Threonine), X5 is an amino acid selected from the group consisting of L (Leucine), Y (Tyrosine) and Q (Glutamine), X6 is an amino acid selected from the group consisting of D (Aspartic acid), N (Asparagine), E (Glutamic acid), S (Serine), G (Glycine) and K (Lysine), X7 is an amino acid selected from the group consisting of D (Aspartic acid), Q (Glutamine), L (Leucine), A (Alanine), K (Lysine) and E (Glutamic acid), which peptide of formula (I) is covalently linked to a carrier protein consisting of a CRM197 protein.