Article comprising calcium for reducing the production of TSST-1

摘要

Articles comprising one or more calcium salts are provided. The articles can contain one or more calcium salts in an amount effective to reduce the production of TSST-1 by at least about 50% when measured by the Shake Flask Method. In certain embodiments, the one or more calcium salts can be substantially non-lethal to Staphylococcus aureus when measured by the Shake Flask Method, and/or to Lactobacillus crispatus, Lactobacillus gasseri, and/or Lactobacillus iners when measured by the Maximum Tolerated Dose Test.

主权项

1. A method for manufacturing a vaginal article, the method comprising the steps of:
a. forming a tampon pledget comprising rayon, wherein the rayon fibers include a calcium salt that was added thereto prior to formation of the tampon pledget; and b. compressing and/or shaping the tampon pledget into a finished tampon configuration that is different than that of the tampon pledget, wherein the calcium salt comprises calcium lactate and/or calcium citrate malate, wherein the calcium salt is included in an amount sufficient to reduce the production of TSST-1 by at least 50% when measured by the Shake Flask Method described herein, and wherein the calcium salt is substantially non-lethal to Lactobacillus crispatus, Lactobacillus gasseri, and Lactobacillus iners when measured by the Maximum Tolerated Dose Test described herein.