Resorbable pouches for implantable medical devices

摘要

Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.

主权项

1. A resorbable pouch comprising
(a) a biodegradable and resorbable polymer formed to at least partially enclose or encase a cardiac rhythm management device, wherein said pouch is configured to permit ingrowth of tissue into said pouch to resist post implantation migration of said cardiac rhythm management device; and (b) one or more drugs, said pouch having a porosity sufficient to electrically ground the device to tissue surrounding said resorbable pouch, wherein said pouch removably encloses or encases said cardiac rhythm management device, and wherein said one or more drugs is selected from the group consisting of an antimicrobial agents, anesthetics, anti-inflammatory agents, and leukotriene inhibitors; wherein the resorbable pouch is a thermoformed clamshell type pouch having a first half and a second half connected by a hinge.