发明名称 |
THERAPEUTIC CANCER VACCINE BASED ON STRESS PROTEINS RENDERED IMMUNOGENIC |
摘要 |
The invention describes a method for preparing a composition comprising tumour cell stress proteins, said method comprising the following steps: providing tumour cells in a culture medium; subjecting the tumour cells under i) to a stress with the result that these cells produce stress proteins in response to the stress; obtaining or recovering stressed tumour cells and/or stress proteins; treating the stressed tumour cells and/or the stress proteins obtained with a molecule or a process capable of rendering the stress proteins immunogenic, preferably a hapten or haptenization. The invention also describes a pharmaceutical composition comprising tumour cell stress proteins and/or tumour cells comprising stress proteins, these stress proteins being rendered immunogenic, and are in particular haptenized, and a pharmaceutically acceptable excipient. |
申请公布号 |
WO2015055733(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
WO2014EP72149 |
申请日期 |
2014.10.15 |
申请人 |
GOLDFISH;PINTEUR, BENOÎT;DEVILLERS, GILLES |
发明人 |
PINTEUR, BENOÎT;DEVILLERS, GILLES |
分类号 |
C07K14/47;A61K35/00;A61K38/17;A61K39/385 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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