NMR measurement of contrast medium concentrations

摘要

A method for measuring the cerebral perfusion of a living organism (1) by means of magnetic resonance (=“MR”) imaging proposes acquisition of further MR signals in a slice (5) that is pervaded by an artery that supplies the blood to the brain in order to determine the temporal progression of the concentration of the contrast medium during the bolus passage in the artery. During acquisition of the further MR signals, a magnetic field gradient is applied in such a way that projection images of the slice are generated. In each time interval between the excitations of the further MR signals, at least one radio-frequency (=“RF”) pulse is irradiated that causes saturation of the nuclear spin magnetization in the slice. This enables simultaneous measurement of the contrast medium flow in the vessels supplying the brain and the brain tissue within the same sequence with an adapted dynamic range.

主权项

1. A method for measuring the cerebral perfusion in a brain of a living organism by means of magnetic resonance (=“MR”) imaging, the method comprising the steps of:
a) measuring a change in an MR signal during passage of a contrast medium bolus in a measurement volume in the brain of the living organism; b) acquiring, in a slice that is pervaded by an artery that supplies blood to the brain, further MR signals to determine a temporal progression of a concentration of the contrast medium during the bolus passage in the artery; c) applying, during step b), a magnetic field gradient in such a way that projection images of the slice are generated; and d) irradiating, in each time interval between excitations of the further MR signals, at least one radio-frequency (=“RF”) pulse that causes saturation of nuclear spin magnetization in the slice.