发明名称 |
Microporation of human skin for drug delivery and monitoring applications |
摘要 |
<p>A method of enhancing the permeability of the skin (120,274) to an analytic for diagnostic purposes or to a drug for therapeutic purposes is described utilizing micro-pore and optionally sonic energy and a chemical enhancer. If selected, the sonic energy may be modulated by means of frequency modulation, amplitude modulation, phase modulation, and/or combinations thereof. Micro-pore is accomplished by (a) ablating the stratum corneum (274) by localized rapid heating of water such that water is vaporized, thus eroding cells; (b) puncturing the stratum corneum (274) which a micro-lancet calibrated to form a micro-pore of up to about 1000 mu m in diameter; (c) ablating the stratum corneum (274) by focusing a tightly focused beam of sonic energy onto the stratum corneum (274); (d) hydraulically puncturing the stratum corneum (274) with a high-pressure jet of fluid to form a micro-pore of up to about 1000 mu m in diameter; or (e) puncturing the stratum corneum (274) with short pulses of electricity to form a micro-pore of up to about 1000 mu m in diameter. <IMAGE></p> |
申请公布号 |
EP1563788(B8) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20050011002 |
申请日期 |
1996.08.29 |
申请人 |
NITTO DENKO CORPORATION |
发明人 |
EPPSTEIN, JONATHAN A.;HATCH, MICHAEL R.;YANG, DIFEI |
分类号 |
A61B10/00;A61B5/00;A61B5/145;A61B5/1486;A61B17/00;A61B17/32;A61B17/3203;A61B18/00;A61B18/08;A61B18/20;A61K41/00;A61M37/00 |
主分类号 |
A61B10/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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