Pharmaceutical composition for therapy of parodonthium deseases

摘要

A pharmaceutical composition for the treatment of periodontitis. A pharmaceutical composition according to the present invention is in the form of a gel with a selected viscosity. Its active ingredient is a base comprising a cysteine protease inhibitor from egg protein, urine, human or animal amniotic fluid, human or animal placentae as well as plants, with an activity of 1 - 50 inhibition units, suspended in 50 g of a polyhydroxyl alcohol and 50 g of a 0.05 molar phosphate buffer solution at a p H of 6.0 to 7.5, from 20 to 50 % by mass, whereas its carrier comprises gelling substances, from 7 to 20 % by mass, as well as water to 100% by mass. The gelling substances may be methylcellulose, hydroxypropylmethyl-cellulose, carboxymethylcellulose sodium salt, gelatin, apple-citrus pectin or a dextran. Preferentially, additives in the form of polyhydroxyl alcohols and Nipagin are used.