METHOD AND IMPROVED PHARMACEUTICAL COMPOSITION FOR ENHANCING TRANSDERMAL DELIVERY OF PDE-5 INHIBITOR

摘要

The present disclosure relates to the use of an agent that enhances transdermal delivery of a PDE-5 inhibitor. More particularly, the present disclosure provides improved method and composition that promotes transdermal delivery of a PDE-5 inhibitor for the treatment of the PDE-5 mediated conditions and/or diseases.

主权项

1. In an improved transdermal pharmaceutical composition comprising a phosphodiesterase type-5 (PDE-5) inhibitor or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the improvement comprises,
an enhancer selected from the group consisting of cocamidopropyl betaine, sodium lauroamphoacetate, quaternium-60, isostearamidopropyl morpholine lactate, dipropylene glycol and a combination thereof; wherein the PDE-5 inhibitor and the enhancer are present in a ratio from about 20:1 to 2:1 in the improved transdermal pharmaceutical composition.