Highly Concentrated Stable Meloxicam Solutions for Needleless Injection

摘要

An aqueous cyclodextrin-free solution of meloxicam suitable is provided for administration by needleless injection, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients.

主权项

1. An aqueous particle free highly concentrated meloxicam solution suitable for administration by needleless injection, comprising:
35 to 100 mg/ml meloxicam; a pharmacologically acceptable organic or inorganic base capable of forming a salt with the meloxicam and selected from the group consisting of meglumine, sodium, potassium and ammonium; and disodium EDTA in an amount such that the weight ratio of meloxicam to disodium EDTA is between 100:1 and 35:1; wherein the solution is free of cyclodextrin, and the solution has a shelf-life after opening of 28 days or more.