NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY

摘要

[Problem] To provide an anti-human TSLP receptor antibody for specifically bonding to the human TSLP receptor and blocking the effect of human TSLP receptor-mediated human TSLP. [Solution] The present inventors studied the anti-human TSLP receptor antibody and have provided an anti-human TSLP receptor antibody that includes a heavy-chain variable region composed of an amino acid sequence from amino acid number 1 to 118 of sequence number 1, and a light-chain variable region composed of an amino acid sequence from amino acid number 1 to 108 of sequence number 3. The present inventors perfected the present invention having found that the anti-human TSLP receptor antibody blocks TSLP-induced expression of TARC mRNA and production of MDC protein, and that allergic reaction is inhibited in a simian ascaris antigen sensitization model.