One pot process for preparing pemetrexed disodium

摘要

This invention relates to one pot process for preparing antifolate agent pemetrexed disodium in pure form.

主权项

1. An efficient process for preparing pemetrexed or its metal salts starting from dialkylester of pemetrexed or salts thereof,
comprising: dissolving or suspending dialkylester of pemetrexed or salts thereof in water or in a water/alcohol mixture; desalting and hydrolyzing ester moieties by using metal hydroxide; adding water soluble metal salts after pH adjustment; and isolating pemetrexed salt from the mixture via filtration.