| 摘要 |
A new efficient method of producing Cinacalcet of formula I and its pharmaceutically acceptable salts, which consists in direct alkylation of (R)-(1-naphthyl)ethylamine of formula III with 3-[3-(trifluoromethyl)phenyl]propanol of formula II in presence of a catalyst in an inert organic solvent. Use of Cinacalcet of formula I prepared by the claimed method in preparation of pharmaceutically acceptable salts of Cinacalcet. |
