发明名称 Treatment of osteoporosis
摘要 According to the invention there is provided a compound of formula (I): wherein R1, R2, R3 and n have meanings given in the description, or a pharmaceutically acceptable solvate, salt or prodrug thereof for use in the treatment of osteoporosis and/or osteopenia.;
申请公布号 US8895624(B2) 申请公布日期 2014.11.25
申请号 US201013518621 申请日期 2010.12.22
申请人 Haoma Medica Ltd. 发明人 Hodges Stephen;Soper Robin
分类号 A61K31/12;C07C49/105;A61K31/122;A61K31/00 主分类号 A61K31/12
代理机构 Cooley LLP 代理人 Cooley LLP
主权项 1. A compound of formula (I) wherein: R1 represents hydrogen, halogen, cyano, trifluoromethyl, nitro, —ORa, SRa, SORa, —SO2Ra, —SO2NRaRb, —NRaRb, —NRaCORb, —NRaCO2Rb, —CORa, —CO2Ra, —CONRaRb, or a hydrocarbon group comprising a straight chain, branched or cyclic group each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatom; R2 represents, independently at each occurrence, hydrogen, halogen, cyano, trifluoromethyl, nitro, —ORa, SRa, SORa, —SO2Ra, —SO2NRaRb, —NRaRb, —NRaCORb, —NRaCO2Rb, —CORa, —CO2Ra, —CONRaRb, or a hydrocarbon group comprising a straight chain, branched or cyclic group each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatom; R3 represents a hydrocarbon group comprising a straight chained, branched or cyclic group each containing up to 18 carbon atoms, and being substituted by at least one moiety including a —CO2Ra substituent; wherein Ra and Rb independently represent, at each occurrence, hydrogen, or a hydrocarbon group comprising a straight chained, branched or cyclic group each containing up to 18 carbon atoms, or a heterocyclic group containing up to 18 carbon atoms and at least one heteroatom; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable solvate salt or prodrug thereof; for use in the treatment of osteoporosis and/or osteopenia.
地址 Essex GB