发明名称 |
BRANCHED AMPHIPATHIC BLOCK POLYMER AND MOLECULAR AGGREGATE AND DRUG DELIVERY SYSTEM USING SAME |
摘要 |
Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer. |
申请公布号 |
EP2725053(A4) |
申请公布日期 |
2014.10.29 |
申请号 |
EP20120802877 |
申请日期 |
2012.06.22 |
申请人 |
SHIMADZU CORPORATION;KYOTO UNIVERSITY |
发明人 |
OZEKI, EIICHI;KIMURA, SHUNSAKU;MAKINO, AKIRA |
分类号 |
C08G81/00;A61K9/10;A61K9/51;A61K47/34;A61K49/00;A61K51/06;B82Y5/00;C08G83/00;C08L67/04 |
主分类号 |
C08G81/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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