SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE AND CORRECTING FOR INTERFERENTS

摘要

Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.

主权项

1. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising:
inserting the test strip into a strip port connector of the test meter to connect at least two electrodes of the test strip to a strip measurement circuit; initiating a test sequence after deposition of a sample; causing a transformation of analytes in the sample from one form to a different form; switching the first voltage to a second voltage different than the first voltage; changing the second voltage to a third voltage different from the second voltage; measuring a second current output of the current transient from the electrodes after the changing from the second voltage to the third voltage; estimating a current that approximates a steady state current output of the current transient after the third voltage is maintained at the electrodes; calculating a blood glucose concentration based on the first, second and third current output of the current transient with an equation of the form:G1=(iril)p(ai2CORR-zgr); where: G1 comprises a glucose concentration;ir=∑t=4.4t=5i(t);il=∑t=1.4t=4i(t);i2(Corr)=(i4.1+bi5-ci1.1i4.1+bi5)ir where:a, b, c, p, zgr comprise manufacturing parameters;i4.1 comprises the current measured at about 4.1 seconds after initiation of test sequence;i5 comprises the current measured at about 5 seconds after initiation of test sequence;i1.1 comprises the current measured at about 1.1 seconds after initiation of test sequence; and correcting the blood glucose concentration with an equation of the form:
Gcorr=G1*(A+B*i1.1)where Gcorr comprises a corrected blood glucose concentration and coefficients A and B comprise empirically derived coefficients.