| 摘要 |
PROBLEM TO BE SOLVED: To provide new diagnostic methods using biomarkers of Alzheimer's disease which are available peripherally from easily obtainable patient samples.SOLUTION: An ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprises: (i) determining the level of expression of at least four platelet proteins in a platelet sample isolated from the patient selected from monoamine oxidase-B, coagulation factor XIIIa, total tropomyosin (α and &bgr;), WD-repeat protein 1 and apolipoprotein E4 (ApoE4); and (ii) comparing the result of (i) to a control value; where a result higher than the control value is indicative of Alzheimer's disease. |
