发明名称 |
PHARMACEUTICAL COMPOSITION OF POLYMER MICROPARTICLES WITH MODIFIED RELEASE KINETICS OF POORLY SOLUBLE DRUG SUBSTANCES |
摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine and describes a pharmaceutical composition of polymer microparticles with modified release kinetics of poorly soluble drug substances. The composition represents a mixture of polymer microparticles having a size of 1 to 100 mcm and consisting of a composite of a biodegradable and biocompatible polymer of poly-3-oxybutyrate or poly-3-oxybutyrate-with-3-oxyvalerate; an active drug substance having a water-solubility of less than 20 mcg/ml, particularly ivermectin; and an additive substance specified in phospholipids and/or polyethylene glycols, and/or poloxamers. The weight ratio of the additive substance to the polymer in the microparticles of the pharmaceutical composition profiles release kinetics of the active drug substance.EFFECT: mixture of microparticles of various modifications enables additional variations of release kinetics of the active drug between the linear to degree nature, and a release rate.18 cl, 3 tbl, 4 dwg |
申请公布号 |
RU2530577(C2) |
申请公布日期 |
2014.10.10 |
申请号 |
RU20120150080 |
申请日期 |
2012.11.23 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "MOSKOVSKIJ GOSUDARSTVENNYJ UNIVERSITET IMENI M.V. LOMONOSOVA" (MGU) |
发明人 |
BONARTSEV ANTON PAVLOVICH;BONARTSEVA GARINA ALEKSANDROVNA;JAKOVLEV SERGEJ GEORGIEVICH;SHAJTAN KONSTANTIN VOL'DEMAROVICH |
分类号 |
A61K9/14;A61K31/34;A61K31/35;A61K47/34 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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