Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof

摘要

The present invention is for method of treating metabolic bone disease, new compounds and pharmaceutical compositions comprising the active ingredients having inhibition effects on osteoclast differentiation. The pharmaceutical composition comprising new compounds according to the present invention can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease.

主权项

1. A method of treating metabolic bone disease comprising: single or multiple administration of pharmaceutical composition comprising a compound of the following formula I, or pharmaceutically acceptable salts thereof as an active ingredient to a patient in need thereof, wherein in Formula I, R1 represents phenyl, C6-10aryl, C6-10arylC1-6alkyl, C3-10cycloalkyl or 5-10 membered heteroaryl including at least one selected from nitrogen atom, oxygen atom and sulfur atom in a ring; R2 and R3 each independently represent halogen, phenyl, hydroxy, C6-10aryl, C6-10arylC1-6alkyl, C3-10cycloalkyl or 5-10 membered heteroaryl including at least one selected from nitrogen atom, oxygen atom and sulfur atom in a ring; and X and Y each independently represent hydrogen, oxo, hydroxy, S or CH2.