| 发明名称 | Drug for suppressing pathogen occurring in vivo | ||
| 摘要 | To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo.;The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to an organ or cells capable of metabolizing or excreting the pathogen and which is bonded to the adsorbent via a linker or with no linker, and to a drug containing the same. | ||
| 申请公布号 | US8834887(B2) | 申请公布日期 | 2014.09.16 |
| 申请号 | US200812679395 | 申请日期 | 2008.09.25 |
| 申请人 | National Cerebral and Cardiovascular Center;Kowa Co., Ltd. | 发明人 | Yamaoka Tetsuji;Shiba Mariko;Mahara Atsushi;Kato Yoshihito |
| 分类号 | A61K39/00;A61K39/385;A61K47/48;A61K38/16;C07K16/28;A61K31/737 | 主分类号 | A61K39/00 |
| 代理机构 | Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to hepatocytes and which is bonded to the adsorbent via a linker having carbonyl group at each end of diamine or glycol, wherein the adsorbent (A) is dextran sulfate or a salt thereof, or dextran sulfate or a salt thereof which is modified with the adsorbent (A). | ||
| 地址 | Suita JP | ||