METHOD FOR DETOXIFYING A BIOLOGICAL TISSUE

摘要

Biological tissues may be prepared for use in biological prostheses. The biological tissue may be fixated with glutaraldehyde and may be subjected to successive treatment of the tissue with a solution containing taurine to neutralize excess aldehyde groups that remain free after fixation.

主权项

1. A method of treating a biological tissue for use in a biological prosthesis, the method comprising the steps:
treating the biological tissue with a detoxification solution comprising taurine at a concentration within the range from 0.10% w/v to saturation at a temperature between 25° C. and 45° C.; and storing a treated biological tissue in a phosphate buffer; wherein treating the biological tissue with the detoxification solution at a temperature range between 25° C. and 45° C. reduces calcification of the biological tissue when compared to treating a biological tissue at 20° C.