NOVEL MULTIPHASIC BIOMATERIALS AND METHOD OF MANUFACTURING SAME

摘要

The novel biomaterial fillers containing cross-linked sodium alginate and the method for manufacturing same are used in the medical field and are intended for filling tissue lesions having a layered structure of varying compositions, such as cartilage, skin or the epithelium. These novel biomaterials have the special feature of being multiphasic, composite and functionalized, for medical use and, in particular, for treating tissue lesions having a layered structure of varying compositions. The biomaterials are particularly suitable for treating focal lesions of the articular cartilage.

主权项

1. Method for manufacturing a cross-linked sodium alginate based biomaterial filler, the method comprising the steps of:
a) preparing a sodium alginate based solution on a basis of 1.5% to 3.0%; b) initiating crosslinking of the sodium alginate based solution by adding a defined quantity in concentration and in volume of calcium sulfate; c) depositing an obtained solution on an inert or functionalized support by airbrush pens; d) reiterating steps a) to c) in order to superimpose various layers of cross-linked sodium alginate on the support; e) once desired thickness has been obtained, proceeding to initiate final crosslinking of biomaterial through atomizing calcium chloride by an airbrush pen; f) proceeding to final crosslinking by dipping a whole obtained biomaterial into a bath of calcium chloride.