| 发明名称 |
Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase |
| 摘要 |
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases. |
| 申请公布号 |
AU2008310628(B2) |
申请公布日期 |
2014.09.04 |
| 申请号 |
AU20080310628 |
申请日期 |
2008.10.10 |
| 申请人 |
UNIVERSITA DEGLI STUDI DI PARMA;UNIVERSITA DEGLI STUDI DI URBINO "CARLO BO";THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PIOMELLI, DANIELE;MOR, MARCO;TONTINI, ANDREA;TARZIA, GIORGIO;DURANTI, ANDREA |
| 分类号 |
A61K8/00;A61K8/18;A61Q5/00 |
主分类号 |
A61K8/00 |
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