发明名称 |
Long term disease modification using immunostimulatory oligonucleotides |
摘要 |
The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification. |
申请公布号 |
US8815817(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US200912992590 |
申请日期 |
2009.05.15 |
申请人 |
Dynavax Technologies Corporation |
发明人 |
Hessel Edith M.;Coffman Robert L. |
分类号 |
A01N43/04;C07H21/02;C12P19/34;C12N15/63 |
主分类号 |
A01N43/04 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A method for treating an individual in need thereof comprising administering to the individual multiple administrations of an effective amount of a CpG-containing ISS wherein the CpG-containing ISS is administered at least 5 times and wherein the administration results in a long term disease modification of allergic rhinitis, wherein the long term disease modification is determined by the reduction of one or more allergic rhinitis symptoms for a period of at least 3 weeks after the last administration of the ISS, and wherein the ISS is administered to the individual from about 3 days to about 4 weeks in between the dosages. |
地址 |
Berkeley CA US |