Tetrahydroquinoline derivatives

摘要

The present invention relates to a compound of formula (I);
or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.

主权项

1. A compound of formula (I) wherein
A1 is nitrogen or —CR10—,A2 is nitrogen or —CH—;A3 is nitrogen or —CR9—;one of R1, R2 and R10 is -A4-SO2−R11 and the other ones are independently selected from the group consisting of hydrogen, alkyl and halogen,A4 is absent or —NR12—C(O)—; R3 and R4 are independently selected from the group consisting of alkyl and phenyl,
or R3 and R4 together with the carbon atom to which they are attached form cycloalkyl,R5, R6, R7, R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, alkoxy, halogen, alkylamino, dialkylamino, hydroxyphenyl, morpholinyl, piperazinyl, alkylpiperazinyl, phenylpiperazinyl, phenylaminocarbonyl, oxo-oxazolidinyl, aminocarbonyl, cyano, alkylsulfonyl, alkylphenyl, alkoxyphenyl, alkylphenylpiperazinyl, dialkylphenylpiperazinyl, halophenylpiperazinyl, alkyl-1H-tetrazolyl, cycloalkyl-1H-tetrazolyl, pyrrolidinyl, carboxyalkylamino and carboxycycloalkylamino,R11 is selected from the group consisting of alkyl, cycloalkyl, alkylamino, cycloalkylamino and morpholinyl, andR12 is hydrogen or alkyl; or a pharmaceutically acceptable salt or ester thereof.