| 发明名称 |
DRY POWDER FORMULATIONS OF ORGANIC MACROMOLECULES |
| 摘要 |
The present invention relates to methods for making a stabilized powder formulation for inhalation comprising a macromolecule in lyophilized form, a crystalline carrier material, and magnesium stearate. |
| 申请公布号 |
US2014219954(A1) |
申请公布日期 |
2014.08.07 |
| 申请号 |
US201414216380 |
申请日期 |
2014.03.17 |
| 申请人 |
Jagotec AG |
发明人 |
Mueller-Walz Rudi |
| 分类号 |
A61K9/14;A61K38/50;A61K38/28;A61K38/48;A61K39/00;A61K39/13;A61K38/47;A61K38/19;A61K39/29 |
主分类号 |
A61K9/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for making a stabilized powder formulation for inhalation having a Fine Particle Fraction (FPF) comprising a macromolecule in lyophilized form, the method comprising the steps of
co-micronizing the macromolecule in bulk form with a carrier material in crystalline form to produce fine particles, and blending the macromolecule and crystalline carrier material with magnesium stearate,wherein, after six months of storage at 40 C/75% relative humidity, the FPF remains at more than 50%. |
| 地址 |
Muttenz CH |
