Monoclonal antibodies against scrapie prion protein (PrPSc), and the use thereof

摘要

The resent invention relates to monoclonal antibodies against PrP Sc protein. The anti-PrP Sc mAbs produced of this invention can specifically detect PrP Sc protein from normal mouse brain homogenates without pre-treatment with protease K, which may be used in developing a diagnostic method and kit for prion disease with high specificity and sensitivity.