METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION
摘要
<p>The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.</p>
申请公布号
EP2751574(A1)
申请公布日期
2014.07.09
申请号
EP20120828485
申请日期
2012.08.30
申请人
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人
LOWARY, TODD LAMBERT;CAIRO, CHRISTOPHER WARREN;WEST, LORI JEANNE;BURIAK, JILLIAN MARY;MELONCELLI, PETER JOHN;JEYAKANTHAN, MYLVAGANAM;SLANEY, ANNE MARGARET