RNAi-related inhibition of TNFα signaling pathway for treatment of ocular angiogenesis

摘要

RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy.

主权项

1. A small interfering RNA (siRNA) molecule comprising a sense strand and an antisense strand, wherein the sense strand is a 19 nucleotide RNA sequence corresponding to SEQ ID NO: 14.