发明名称 |
MONOCLONAL ANTIBODY AND ANTIGENS FOR DIAGNOSING AND TREATING LUNG DISEASE AND INJURY |
摘要 |
<p>The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression.</p> |
申请公布号 |
EP2717913(A2) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20120797368 |
申请日期 |
2012.06.08 |
申请人 |
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
CLAUSS, MATTHIAS;PETRACHE, IRINA;VOSWINCKEL, ROBERT |
分类号 |
A61K39/395;A61K39/00;A61P11/00;A61P35/00;C07K16/18;C07K16/22;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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