HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES

摘要

HIV replication inhibitors of formula R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; R2, R3, R6 and R7 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy;—C(═O)R9; optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R4 and R5 are hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; formyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy;—C(═O)R9; cyano;—S(═O)rR9;—NH—S(═O)2R9;—NHC(═O)H;—C(═O)NHNH2;—NHC(═O)R9; Het;—Y-Het; optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R5 is pyridyl,—C(═O)NR5aR5b;—CH(OR5c)R5d;—CH2—NR5eR5f;—CH═NOR5a;—CH2—O—C2-6alkenyl;—CH2—O—P(═O)(OR5g)2;—CH2—O—C(═O)—NH2;—C(═O)—R5d; X is—NR1—,—O—,—CH2—,—S—; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions.