BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
摘要
<p>In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.</p>
申请公布号
EP2648723(A4)
申请公布日期
2014.04.02
申请号
EP20110847759
申请日期
2011.12.07
申请人
VANDERBILT UNIVERSITY
发明人
CONN, P., JEFFREY;LINDSLEY, CRAIG, W.;STAUFFER, SHAUN, R.;JONES, CARRIE, K.;CONDE-CEIDE, SUSANA;TONG, HAN MIN;BARTOLOME-NEBREDA, JOSE, MANUEL;MACDONALD, GREGOR, JAMES