发明名称 |
PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES |
摘要 |
The invention relates to a novel process for preparing enantiomerically enriched or pure tetrahydroquinoline derivatives by reacting a chiral dihydropyran-methylamine C with a aldehyde B and an aniline A in a multicomponent one pot synthesis in the presence of a protonic acid or lewis acid with a suitable solvent. A, B, C have the meaning as described in the specification. (see formula A) (see formula B) (see formula C) |
申请公布号 |
CA2709571(C) |
申请公布日期 |
2014.03.11 |
申请号 |
CA20082709571 |
申请日期 |
2008.11.20 |
申请人 |
MERCK PATENT GMBH |
发明人 |
EMDE, ULRICH;BLOCK, OLIVIER;SCHIEMANN, KAI |
分类号 |
C07D491/052;C07D309/20 |
主分类号 |
C07D491/052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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