2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
摘要
The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-&bgr; (TGF-&bgr;) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.
申请公布号
AU2012281281(A1)
申请公布日期
2014.03.06
申请号
AU20120281281
申请日期
2012.07.13
申请人
SK CHEMICALS CO., LTD.
发明人
LEE, JU YOUNG;RYU, KEUN-HO;KIM, JAE-SUN;KIM, YONG-HYUK;SHIN, DONG CHUL;LEE, BONG-YONG;KANG, SANG-HWAN;LEE, HYUN JUNG;JUNG, HOECHUL;SHIN, YOUNG AH;PARK, EUISUN;AHN, JAESEUNG