发明名称 |
Process for improved protein expression by strain engineering |
摘要 |
This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein. |
申请公布号 |
US8603824(B2) |
申请公布日期 |
2013.12.10 |
申请号 |
US20050189375 |
申请日期 |
2005.07.26 |
申请人 |
RAMSEIER THOMAS M.;JIN HONGFAN;SQUIRES CHARLES H.;PFENEX, INC. |
发明人 |
RAMSEIER THOMAS M.;JIN HONGFAN;SQUIRES CHARLES H. |
分类号 |
C12N15/67;C12N15/52;C12N15/63;C12N15/64;C12N15/65 |
主分类号 |
C12N15/67 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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